Cas clinique du Dr. William Bucknam

SUPPRESSION OF SYMPTOMS OF ALCOHOL DEPENDENCE AND CRAVING USING HIGH-DOSE BACLOFEN

WILLIAM BUCKNAM 1 *

1 No. 207, 5340 Plymouth Road, Ann Arbor, MI 48105, USA

 

* To whom correspondence should be addressed.
WILLIAM BUCKNAM, E-mail: wbucknam@hotmail.com

 

  Abstract :

Aims: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. Methods: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. Results: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. Conclusions: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.

 

 

 

© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved
Received July 14, 2006
Revised August 18, 2006
Accepted September 5, 2006

 

Lien : http://alcalc.oxfordjournals.org/cgi/content/abstract/agl091v1

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